publications

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2018

Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates
P. Moscariello, D.Y.W. Ng, M. Jansen, T. Weil, H.J. Luhmann, J. Hedrich
Adv. Sci. 1700897, 1700897 (2018). → doi: 10.1002/advs.201700897

Importance of the IL-1 Axis in Haemophilus influenzae–stimulated M1 Macrophages Driving Transepithelial Signaling
S. Mang, A. Braun, N. Pairet, D.J. Lamb
Am. J. Respir. Cell Mol. Biol. 58, 412 (2018). → doi: 10.1165/rcmb.2017-0283LE 

Effects of arsenolipids on in vitro blood-brain barrier model
S.M. Müller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Hüwel, H.-J. Galla, K.A. Francesconi, T. Schwerdtle
Arch. Toxicol. 92, 823 (2018). → doi: 10.1007/s00204-017-2085-8

Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain
W. Neuhaus, A. Piontek, J. Protze, M. Eichner, A. Mahringer, E.-A. Subileau, I.-F.M. Lee, J.D. Schulzke, G. Krause, J. Piontek
Biomaterials 161, 129 (2018). → doi: 10.1016/j.biomaterials.2018.01.028

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
E. Melo, P. Oertle, C. Trepp, H. Meistermann, T. Burgoyne, L. Sborgi, A.C. Cabrera, Ch.-Y. Chen, J.-Ch. Hoflack, T. Kam-Thong, R. Schmucki, L. Badi, N. Flint, Z.E. Ghiani, F. Delobel, C. Stucki, G. Gromo, A. Einhaus, B. Hornsperger, S. Golling, J. Siebourg-Polster, F. Gerber, B. Bohrmann, C. Futter, T. Dunkley, S. Hiller, O. Schilling, V. Enzmann, S. Fauser, M. Plodinec, R. Iaconet
EBioMedicine 27, 258 (2018). → doi: 10.1016/j.ebiom.2017.12.011

Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity
Z. Maherally, H.L. Fillmore, S.L. Tan, S.F. Tan, S.A. Jassam, F.I. Quack, K.E. Hatherell, G.J. Pilkington
FASEB J. 32, 168 (2018). → doi: 10.1096/fj.201700162R

Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption
R. Vutukuri, R. Brunkhorst, R.-I. Kestner, L. Hansen, N.F. Bouzas, J. Pfeilschifter, K. Devraj, W. Pfeilschifter
J. Neurochem. 144, 172 (2018). → doi: 10.1111/jnc.14236

Bovine dairy complex lipids improve in vitro measures of small intestinal epithelial barrier integrity
R.C. Anderson, A.K.H. MacGibbon, N. Haggarty, K.M. Armstrong, N.C. Roy
PLoS One 13, e0190839 (2018). → doi: 10.1371/journal.pone.0190839

Rhombic organization of microvilli domains found in a cell model of the human intestine
J. Franz, J. Grünebaum, M. Schäfer, D. Mulac, F. Rehfeldt, K. Langer, A. Kramer, Ch. Riethmüller
PLoS One 13, e0189970 (2018). → doi: 10.1371/journal.pone.0189970

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis
M. Ribecco-Lutkiewicz, C. Sodja, J. Haukenfrers, A.S. Haqqani, D. Ly, P. Zachar, E. Baumann, M. Ball, J. Huang, M. Rukhlova, M. Martina, Q. Liu, D. Stanimirovic, A. Jezierski, M. Bani-Yaghoub
Sci. Rep. 8, 1873 (2018). → doi: 10.1038/s41598-018-19522-8

Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids
B. van der Hee, L.M.P. Loonen, N. Taverne, J.J. Taverne-Thiele, H. Smidt, J.M. Wells
Stem Cell Res. 28, 165 (2018). → doi: 10.1016/j.scr.2018.02.013

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy
N. Zhang, F. Yan, X. Liang, M. Wu, Y. Shen, M. Chen, Y. Xu, G. Zou, P. Jiang, C. Tang, H. Zheng, Z. Dai
Theranostics 8, 2264 (2018). → doi: 10.7150/thno.23734

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2017

Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials
J. Strehlau, T. Weber, C. Lürenbaum, J.Bornhorst, H.-J. Galla, T. Schwerdtle, M. Winter, S. Nowak
Anal. Bioanal. Chem. 409, 6123 (2017). → doi: 10.1007/s00216-017-0549-6

Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function
A. Raya-Sandino, A. Castillo-Kauil, A. Domínguez-Calderón, L. Alarcón, D. Flores-Benitez, F. Cuellar-Perez, B. López-Bayghen, B. Chávez-Munguía, J. Vázquez-Prado, L. González-Mariscal
Biochim. Biophys. Acta Mol. Cell Res. 1864, 1714 (2017). → doi: 10.1016/j.bbamcr.2017.05.016

Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease
Ch. Ruland, H. Renken, I. Kuzmanov, A.F. Mehr, K. Schwarte, M. Cerina, A. Herrmann, D.-M. Otte, A. Zimmer, N. Schwab, S.G. Meuth, V. Arolt, L. Klotz, I. Förster, S. Scheu, J. Alferink
Brain Behav. Immun. 66, 382 (2017). → doi: 10.1016/j.bbi.2017.06.010

Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D
S. Demolli, A. Doddaballapur, K. Devraj, K. Stark, Y. Manavski, A. Eckart, Ch.M. Zehendner, T. Lucas, T. Korff, M. Hecker, S. Massberg, S. Liebner, D. Kaluza, R.A. Boon, S. Dimmeler
Cardiovasc. Res. 113, 681 (2017). → doi: 10.1093/cvr/cvx032

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration
J. Song, X. Zhang, K. Buscher, Y. Wang, H. Wang, J. Di Russo, L. Li, L. Lütke-Enking, A. Zarbock, A. Stadtmann, P. Striewski, B. Wirth, I. Kuzmanov, H. Wiendl, D. Schulte, D. Vestweber, L. Sorokin
Cell Rep. 18, 1256 (2017). → doi: 10.1016/j.celrep.2016.12.092

The ESRP1-GPR137 axis contributes to intestinal pathogenesis
L.F. Mager, V.H. Koelzer, R. Stuber, L. Thoo, I. Keller, I. Koeck, M. Langenegger, C. Simillion, S.P. Pfister, M. Faderl, V. Genitsch, I. Tcymbarevich, P. Juillerat, X. Li, Y. Xia, E. Karamitopoulou, R. Lyck, I. Zlobec, S. Hapfelmeier, R. Bruggmann, K.D. McCoy, A.J. Macpherson, Ch. Müller, B. Beutler, P. Krebs
eLife 6, e28366 (2017). → doi: 10.7554/eLife.28366

Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice
A. Feldner, M.G. Adam, F. Tetzlaff, I. Moll, D. Komljenovic, F. Sahm, T. Bäuerle, H. Ishikawa, H. Schroten, T. Korff, I. Hofmann, H. Wolburg, A. von Deimling, A. Fischer
EMBO Mol. Med. 9, 890 (2017). → doi: 10.15252/emmm.201606430

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line
C. Guccione, M. Oufir, V. Piazzini, D.E. Eigenmann, E.A. Jähne, V. Zabela, M.T. Faleschini, M.C. Bergonzi, M. Smiesko, M. Hamburger, A.R. Biliat
Eur. J. Pharm. Biopharm. 119, 253 (2017). → doi: 10.1016/j.ejpb.2017.06.018

Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells
J. Venugopal, J. McDermott, G. Sanchez, M. Sharma, L. Barbosa, G.A. Reif, D.P. Wallace, G. Blancot
Exp. Cell Res. 355, 142 (2017). → doi: 10.1016/j.yexcr.2017.04.001

Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells
F. Storti, G. Raphael, V. Griesser, K. Klee, F. Drawnel, C. Willburger, R. Scholz, T. Langmann, A. von Eckardstein, J. Fingerle, Ch. Grimm, C. Maugeais
Exp. Eye Res. 165, 65 (2017). → doi: 10.1016/j.exer.2017.09.008

Gb3-binding lectins as potential carriers for transcellular drug delivery
S.K. Müller, I. Wilhelm, T. Schubert, K. Zittlau, A. Imberty, J. Madl, T. Eierhoff, R. Thuenauer, W. Römer
Expert Opin. Drug Delivery 14, 141 (2017). → doi: 10.1080/17425247.2017.1266327

Primary porcine brain endothelial cells as in vitro model to study effects of ultrasound on blood-brain barrier function
S. Lélu, M. Afadzi, S. Berg, A.K.O. Åslund, S.H. Torp, W. Sattler, C. de L. Davies
IEEE Trans. Sonics Ultrason. 64, 281 (2017). → doi: 10.1109/TUFFC.2016.2597004

Influence of the Fruit Juice Carriers on the Ability of Lactobacillus plantarum DSM20205 to Improve in Vitro Intestinal Barrier Integrity and Its Probiotic Properties
E. Valero-Cases, N.C. Roy, M.J. Frutos, R.C. Anderson
J. Agric. Food Chem. 65, 5632 (2017).

Catalytically enhanced organic transistors for in vitro toxicology monitoring through hydrogel entrapment of enzymes
X. Strakosas, M. Huerta, M.J. Donahue, A. Hama, A.-M. Pappa, M. Ferro, M. Ramuz, J. Rivnay, R.M. Owens
J. Appl. Polym. Sci. 134, 44483 (2017).

Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity
N. Tyagi, N.F. Attia, K.E. Geckeler
J. Colloid Interface Sci. 8, 894 (2017).

Early-lactation, but not mid-lactation, bovine lactoferrin preparation increases epithelial barrier integrity of Caco-2 cell layers
R. C. Anderson, S.A. Bassett, N.W. Haggarty, P.K. Gopal, K.M. Armstrong, N.C. Roy
J. Dairy Sci. 100, 886 (2017).

Real-time monitoring of trans-epithelial electrical resistance in cultured intestinal epithelial cells: the barrier protection of water-soluble dietary fiber
A. Majima, O. Handa, Y. Naito, Y. Suyama, Y. Onozawa, Y. Higashimura, K. Mizushima, M. Morita, Y. Uehara, H. Horie, T. Iida, A. Fukui, O. Dohi, T. Okayama, N. Yoshida, K. Kamada, K. Katada, K. Uchiyama, T. Ishikawa, T. Takagi, H. Konishi, Z. Yasukawa, M. Tokunaga, T. Okubo, Y. Itoh
J. Dig. Dis. 18, 151 (2017).

Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation
E. Rahn, K. Thier, P. Petermann, M. Rübsam, P. Staeheli, S. Iden, C.M. Niessen, D. Knebel-Mörsdorf
J. Invest. Dermatol. 137, 884 (2017).

Effect of Hops Derived Prenylated Phenols on TNF-a Induced Barrier Dysfunction in Intestinal Epithelial Cells
S. Luescher, C. Urmann, V. Butterweck
J. Nat. Prod. 80, 925 (2017).

Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
L. Stolz, A. Derouiche, K. Devraj, F. Weber, R. Brunkhorst, Ch. Foerch
J. Neuroinflammation 14, 152 (2017).

Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems
B. Jonckx, M. Porcu, A. Candi, I. Etienne, P. Barbeaux, J.H.M. Feyen
J. Ophthalmol. 2017, 2060765 (2017).

Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling
Ch. Terciolo, A. Dobric, M. Ouaissi, C. Siret, G. Breuzard, F. Silvy, B. Marchiori, S. Germain, R. Bonier, A. Hama, R. Owens, D. Lombardo, V. Rigot, F. André
JCC 11, 999 (2017).

Insights from mathematical modelling for T cell migration into the central nervous system
T. Ruck, S. Bittner, S.G. Meuth, M. Herty
Math. Med. Biol. 34, 39 (2017).

Establishment of a method for evaluating endothelial cell injury by tnF-α in vitro for clarifying the pathophysiology of virus-associated acute encephalopathy
K. Miyazaki, K. Hashimoto, M. Sato, M. Watanabe, N. Tomikawa, S. Kanno, Y. Kawasaki, N. Momoi, M. Hosoya
Pediatr. Res. (2017).

Development of Blood-Brain Barrier Permeable Nanoparticles as Potential Carriers for Salvianolic Acid B to CNS
Cristina Grossi, C. Guccione, B. Isacchi, M.C. Bergonzi, I. Luccarini, F. Casamenti, A.R: Bilia
Planta Med. 83, 382 (2017).

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells
A. Appelt-Menzel, A. Cubukova, K. Günther, F. Edenhofer, J. Piontek, G. Krause, T. Stüber, H. Walles, W. Neuhaus, M. Metzger
Stem Cell Rep. 498, 364 (2017).

Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity
N. Tyagi, N.F. Attia, K.E. Geckeler
J. Colloid Interface Sci. 8, 894 (2017).

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration
J. Song, X. Zhang, K. Buscher, Y. Wang, H. Wang, J. Di Russo, L. Li, L. Lütke-Enking, A. Zarbock, A. Stadtmann, P. Striewski, B. Wirth, I. Kuzmanov, H. Wiendl, D. Schulte, D. Vestweber, L. Sorokin
Cell Rep. 18, 1256 (2017).

Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis
M.-A. Lécuyer, O. Saint-Laurent, L. Bourbonnière, S. Larouche, C. Larochelle, L. Michel, M. Charabati, M. Abadier, S. Zandee, N.H. Jahromi, E. Gowing, C. Pittet, R. Lyck, B. Engelhardt, A. Prat
PNAS 114, E524 (2017).

Gb3-binding lectins as potential carriers for transcellular drug delivery
S.K. Müller, I. Wilhelm, T. Schubert, K. Zittlau, A. Imberty, J. Madl, T. Eierhoff, R. Thuenauer, W. Römer
Expert Opin. Drug Delivery 14, 141 (2017).

Early-lactation, but not mid-lactation, bovine lactoferrin preparation increases epithelial barrier integrity of Caco-2 cell layers
R. C. Anderson, S.A. Bassett, N.W. Haggarty, P.K. Gopal, K.M. Armstrong, N.C. Roy
J. Dairy Sci. 100, 886 (2017).

Primary porcine brain endothelial cells as in vitro model to study effects of ultrasound on blood-brain barrier function
S. Lélu, M. Afadzi, S. Berg, A.K.O. Åslund, S.H. Torp, W. Sattler, C. de L. Davies
IEEE Trans. Sonics Ultrason. 64, 281 (2017).

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2016

Perilla Frutescens targets intestinal permeability In vitro study on TNF- α stress-induced barrier dysfunction in intestinal epithelial cells
S. Buchwald-Werner, S. Lüscher, S. Kudo, V. Butterweck
Agro Food Ind. Hi-Tech 27, 13(2016).

Toxicological characterisation of a thio-arsenosugar-glycerol in human cells
F. Ebert, S. Meyer, L. Leffers, G. Raber, K.A. Francesconi, T. Schwerdtle
J. Trace Elem. Med. Biol. 38, 150 (2016).

Catalytically enhanced organic transistors for in vitro toxicology monitoring through hydrogel entrapment of enzymes
X. Strakosas, M. Huerta, M.J. Donahue, A. Hama, A.-M. Pappa, M. Ferro, M. Ramuz, J. Rivnay, R.M. Owens
J. Appl. Polym. Sci. 134, 1097-4628 (2016).

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
J.T. Regula, P. Lundh von Leithner, R. Foxton, V.A. Barathi, C.M.G. Cheung, S.B.B. Tun, Y.S. Wey, D. Iwata, M. Dostalek, J. Moelleken, K.G. Stubenrauch, E. Nogoceke, G. Widmer, P. Strassburger, M.J. Koss, Ch. Klein, D.T. Shima, G. Hartmann
EMBO Mol. Med. 8, 1265 (2016).

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
I. Kuzmanov, A.M. Herrmann, H.-J. Galla, S.G. Meuth, H. Wiendl, L. Klotz
J. Vis. Exp. 118 (2016).

MicroRNA-320a Strengthens Intestinal Barrier Function and Follows the Course of Experimental Colitis
F. Cordes, M. Brückner, P. Lenz, K. Veltman, R. Glauben, B. Siegmund, K. Hengst, M.A. Schmidt, Ch. Cichon, D. Bettenworth
Inflammatory Bowel Dis. 22, 2341 (2016).

Influence of Bovine Whey Protein Concentrate and Hydrolysate Preparation Methods on Motility in the Isolated Rat Distal Colon
J.E. Dalziel, R.C. Anderson, S.A. Bassett, C.M. Lloyd-West, N.W. Haggarty, N.C. Roy
Nutrients 8, 809 (2016).

B7-H1 shapes T-cell–mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity
L. Klotz, I. Kuzmanov, S. Hucke, C.C. Gross, V. Posevitz, A. Dreykluft, A. Schulte-Mecklenbeck, C. Janoschka, M. Lindner, M. Herold, N. Schwab, I. Ludwig-Portugall, Ch. Kurts, S.G. Meuth, T. Kuhlmann, H. Wiendl
PNAS 113, E6182 (2016).

Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
E.A. Jähne, D.E. Eigenmann, Ch. Sampath, V. Butterweck, M. Culot, R. Cecchelli, F. Gosselet, F.R. Walter, M.A. Deli, M. Smieško, M. Hamburger, M. Oufir
Planta Med. 82, 1021 (2016).

Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro and ex vivo study
Á. Nyúl-Tóth, M. Suciu, J. Molnár, C. Fazakas, J. Haskó, H. Herman, A.E. Farkas, J. Kaszaki, A. Hermenean, I. Wilhelm, I.A. Krizbai
Am. J. Physiol. 310, H1702 (2016).

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs
D.E. Eigenmann, C. Dürig, E.A. Jähne, M. Smieško, M. Culot, F. Gosselet, R. Cecchelli, H.Ch.C. Helms, B. Brodin, L. Wimmer, M.D. Mihovilovic, M. Hamburger, M. Oufir
Eur. J. Pharm. Biopharm. 103, 118 (2016).

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier
S.E. Storck, S. Meister, J. Nahrath, J.N. Meißner, N. Schubert, A. Di Spiezio, S. Baches, R.E. Vandenbroucke, Y. Bouter, I. Prikulis, C. Korth, S. Weggen, A. Heimann, M. Schwaninger, T.A. Bayer, C.U. Pietrzik
J. Clin. Invest. 126, 123 (2016).

ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug
J.H. Lee, A. Sahu, W.I. Choi, J.Y. Lee, G. Tae
Biomaterials 103, 160 (2016).

β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function
N. Ziegler, K. Awwad, B. Fisslthaler, M. Reis, K. Devraj, M. Corada, S.P. Minardi, E. Dejana, K.H. Plate, I. Fleming, S. Liebner
J. Neurosci. 36, 8921 (2016).

Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
F. Moradi-Afrapoli, M. Oufir, F.R. Walter, M.A. Deli, M. Smiesko, V. Zabela, V. Butterweck, M. Hamburger
J. Pharm. Biomed. Anal. 128, 264 (2016).

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
K. Göbel, S. Pankratz, Ch.-M. Asaridou, A.M. Herrmann, S. Bittner, M. Merker, T. Ruck, S. Glumm, F. Langhauser, P. Kraft, T.F. Krug, J. Breuer, M. Herold, C.C. Gross, D. Beckmann, A. Korb-Pap, M.K. Schuhmann, S. Kuerten, I. Mitroulis, C. Ruppert, M.W. Nolte, C. Panousis, L. Klotz, B. Kehrel, T. Korn, H.F. Langer, T. Pap, B. Nieswandt, H. Wiendl, T. Chavakis, Ch. Kleinschnitz, S.G. Meuth
Nat. Commun. 7, 11626 (2016).

Flurbiprofen-loaded Nanoparticles Can Cross a Primary Porcine In vitro Blood-brain Barrier Model to Reduce Amyloid-β42 Burden
J. Stab, I. Zlatev, B. Raudszus, S. Meister, C.U. Pietrzik, K. Langer, H. von Briesen, S. Wagner
J. Nanomed. Biother. Discovery 6, 1000140 (2016).

Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 045003 (2016).

Transient receptor potential A1 channels regulate epithelial cell barriers formed by MDCK cells
S. Dembla, N. Hasan, A. Becker, A. Beck, S.E. Philipp
FEBS Lett. 590, 1509 (2016).

Plasmalemma Vesicle–Associated Protein Has a Key Role in Blood-Retinal Barrier Loss
J. Wisniewska-Kruk, A.-E. van der Wijk, H.A. van Veen, T.G.M.F. Gorgels, I.M.C. Vogels, D. Versteeg, C.J.F. Van Noorden, R.O. Schlingemann, I. Klaassen
Am. J. Pathol. 186, 1044 (2016).

Angiopoietin‑2‑induced blood–brain barrier compromise and increased stroke size are rescued by VE‑PTP‑dependent restoration of Tie2 signaling
S. Gurnik, K. Devraj, J. Macas, M. Yamaji, J. Starke, A. Scholz, K. Sommer, M. Di Tacchio, R. Vutukuri, H. Beck, M. Mittelbronn, C. Foerch, W. Pfeilschifter, S. Liebner, K.G. Peters, K.H. Plate, Y. Reiss
Acta Neuropathol. 131, 753 (2016).

Modeling immune functions of the mouse blood–cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier
I. Lazarevic, B. Engelhardt
Fluids Barriers CNS 13, 2 (2016).

Targeting of the kynurenic acid across the blood–brain barrier by core-shell nanoparticles
N. Varga, E. Csapó, Z. Majláth, I. Ilisz, I.A. Krizbai, I. Wilhelm, L. Knapp, J. Toldi, L. Vécsei, I. Dékány
Eur. J. Pharm. Sci. 86, 67 (2016).

Secretion of Alpha-Hemolysin by Escherichia coli Disrupts Tight Junctions in Ulcerative Colitis Patients
H.C. Mirsepasi-Lauridsen, Z. Du, C. Struve, G. Charbon, J. Karczewski, K.A. Krogfelt, A.M. Petersen, J.M. Wells
Clin. Transl. Gastroenterol. 7, e149 (2016).

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
P.G. Sreekumar, K. Ishikawa, C.S., H.H. Mehta, J. Wan, K. Yen, P. Cohen, R. Kannan, D.R. Hinton
Invest. Ophthalmol. Visual Sci. 57, 1238 (2016).

The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells
M. Kaiser, S.Chalapala, C. Gorzelanny, R.S. Perali, F.M. Goycoolea
J. Pharm. Sci. 105, 630 (2016).

Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission
K. Valere, A. Rapista, E. Eugenin, W. Lu, T.L. Chang
Viral Immunol. 28, 609 (2016).

Validation of an immortalized human (hBMEC) in vitro blood-brain barrier model
D.E. Eigenmann, E.A. Jähne, M. Smieško, M. Hamburger, M. Oufir
Anal. Bioanal. Chem. 408, 2095 (2016).

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2015

Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers
J. Rivnay, P. Leleux, A. Hama, M. Ramuz, M. Huerta, G.G. Malliaras, R.M. Owens
Sci. Rep. 5, 11613 (2015).

ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis
S.E. Herberich, R. Klose, I. Moll, W.-J. Yang, J. Wüstehube-Lausch, A. Fischer
PLoS One 10, e0145304 (2015).

Claudin-4 binder C-CPE 194 enhances effects of anticanceragents on pancreatic cancer cell lines via a MAPK pathway
K. Tsuyoshi, K. Masuo, K. Daisuke, I. Tatsuya, K. Yasutoshi, I. Masafumi, K. Takayuki, K. Takumi, F. Tomohisa, S. Norimasa, H. Koichi, K. Takashi
Pharmacol. Res. Perspect. 3, e00196 (2015).

Non-Saccharomyces yeasts protect against epithelial cell barrier disruption induced by Salmonella enterica subsp. enterica serovar Typhimurium
I.M. Smith, A. Baker, N. Arneborg, L. Jespersen
Lett. Appl. Microbiol. 61, 491 (2015).

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier
A. Bernd, M. Ott, H. Ishikawa, H. Schroten, C. Schwerk, G. Fricker
Pharm. Res. 32, 2973 (2015).

Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–spinal cord barrier model
S. Meister, S. Storck, E. Hameister, C. Behl, S. Weggen, A. Clement, C. Pietrzik
J. Cereb. Blood Flow Metab. 35, 1112 (2015).

Transport of treosulfan and temozolomide across an in-vitro blood-brain barrier model
U. Linz, M. Hupert, B. Santiago-Schübel, S. Wien, J. Stab, S. Wagner
Anticancer Drugs 26, 728 (2015).

Arsenic-containing hydrocarbons and arsenic-containing fatty acids: Transfer across and presystemic metabolism in the Caco-2 intestinal barrier model
S. Meyer, G. Raber, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 59, 2044 (2015).

Irsogladine Maleate Regulates Gap Junctional Intercellular Communication-Dependent Epithelial Barrier in Human Nasal Epithelial Cells
R. Miyata, K. Nomura, T. Kakuki, K. Takano, T. Kohno, T. Konno, N. Sawada, T. Himi, T. Kojima
J. Membr. Biol. 248, 327 (2015).

Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 045003 (2015).

Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation
I.A. Krizbai, Á. Gasparics, P. Nagyoszi, C. Fazakas, J. Molnár, I. Wilhelm, R. Bencs, L. Rosivall, A. Sebe
PLoS One 10, e0123845 (2015).

The blood–cerebrospinal fluid barrier – first evidence for an active transport of organic mercury compounds out of the brain
H. Lohren, J. Bornhorst, H.J. Galla, T. Schwerdtle
Metallomics 7, 1420 (2015).

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches
A. Wolff, M. Antfolk, B. Brodin, M. Tenje
J. Pharm. Sci. 104, 2727 (2015).

Organic electrochemical transistors for cell-based impedance sensing
J. Rivnay, M. Ramuz, P. Leleux, A. Hama, M. Huerta, R.M. Owens
Appl. Phys. Lett. 106, 043301 (2015).

Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers
C. Staat, C. Coisne, S. Dabrowski, S.M. Stamatovic, A.V. Andjelkovic, H. Wolburg, B. Engelhardt, I.E. Blasig
Biomaterials 54, 9 (2015).

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier
M. Abadier, J. Haghayegh Jahromi, L. Cardoso Alves, R. Boscacci, D. Vestweber, S. Barnum, U. Deutsch, B. Engelhardt, R. Lyck
Eur. J. Immunol. 45, 1043 (2015).

Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells
M. Kaiser, S. Pereira, L. Pohl, S. Ketelhut, B. Kemper, C. Gorzelanny, H.J. Galla, B. M. Moerschbacher, F.M. Goycoolea
Sci. Rep. 5, 10048 (2015).

Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-Fitting
M. Sakurai-Yageta, T. Maruyama, T. Suzuki, K. Ichikawa, Y. Murakami
PLoS One 10, e0116637 (2015).

Live Faecalibacterium prausnitzii in an apical anaerobic model of the intestinal epithelial barrier
D. Ulluwishewa, R.C. Anderson, W. Young, W.C. McNabb, P. van Baarlen, P.J. Moughan, J.M. Wells, N.C. Roy
Cell Microbiol. 17, 226 (2015).

Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood–brain barrier, in human whole blood and in vivo
M. Kolter , M. Ott, C. Hauer, I. Reimold, G. Fricker
J. Control Release 197, 165 (2015).

Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier
M. Lautenschläger, J. Sendker, S. Hüwel, H.J. Galla, S. Brandt, M. Düfer, K. Riehemann, A. Hensel
Phytomed. 22, 36 (2015).

 

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2014

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro
S. Cramer, S. Tacke, J. Bornhorst, J. Klingauf, T. Schwerdtle, H.-J. Galla
J. Nanomed. Nanotechnol. 5, 225 (2014).

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation
K. Ridder, S. Keller, M. Dams, A.-K. Rupp, J. Schlaudraff, D. Del Turco, J. Starmann, J. Macas, D. Karpova, K. Devraj, C. Depboylu, B. Landfried, B. Arnold, K.H. Plate, G. Höglinger, H. Sültmann, P. Altevogt, S. Momma
PLoS Biol. 12, e1001874 (2014).

Freeze-drying of HI-6-loaded recombinant human serum albumin nanoparticles for improved storage stability
M. Dadparvar, S. Wagner, S. Wien, F. Worek, H. von Briesen, J. Kreuter
Euro. J. Pharm. Biopharm. 88, 510 (2014).

Differential apicobasal VEGF signaling at vascular blood-neural barriers
N. Hudson, M.B. Powner, M.H. Sarker, T. Burgoyne, M. Campbell, Z.K. Ockrim, R. Martinelli, C.E. Futter, M.B. Grant, P.A. Fraser, D.T. Shima, J. Greenwood, P. Turowski
Dev. Cell. 30, 541 (2014).

Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats
E.G. Christensen, T.R. Licht, T.D. Leser, M.I. Bahl
BMC Res. Notes 7, 660 (2014).

Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models
E.A. Jähne, D.E. Eigenmann, M. Culot, R. Cecchelli, F.R. Walter, M.A. Deli, R. Tremmel, G. Fricker, M. Smiesko, M. Hamburger, M. Oufir
J. Pharm. Biomed. Anal. 98, 235 (2014).

Synthesis and Pharmacological Evaluation of 5-Pyrrolidinylquinoxalines as a Novel Class of Peripherally Restricted κ-Opioid Receptor Agonists
C. Bourgeois, E. Werfel, F. Galla, K. Lehmkuhl, H. Torres-Gómez, D. Schepmann, B. Kögel, T. Christoph, W. Straßburger, W. Englberger, M. Soeberdt, S. Hüwel, H.-J. Galla, B. Wünsch
J. Med. Chem. 57, 6845 (2014).

Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice
M. Jin, J.-H. Kim, E. Jang, Y.M. Lee, H.S. Han, D.K. Woo, D.H. Park, H. Kook, K. Suk
J. Cereb. Blood Flow Metab. 34, 1306 (2014).

The antimicrobial protein S100A7/psoriasin enhances theexpression of keratinocyte differentiation markers andstrengthens the skin’s tight junction barrier
F. Hattori, C. Kiatsurayanon, K. Okumura, H. Ogawa, S. Ikeda, K. Okamoto, F. Niyonsaba
Br. J. Dermatol. 171, 742 (2014).

The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function
T: Akiyama, F: Niyonsaba, Ch. Kiatsurayanon, T.T. Nguyen, H. Ushio, T. Fujimura, T. Ueno, K. Okumura, H. Ogawa, S. Ikeda
J. Innate Immun. 6, 739 (2014).

The M1 Protein of Streptococcus pyogenes Triggers an Innate Uptake Mechanism into Polarized Human Endothelial Cells
A. Ochel, M. Rohde, G.S. Chhatwal, S.R. Talay
J. Innate Immun. 6, 585 (2014).

PACAP Enhances Barrier Properties of Cerebral Microvessels
I. Wilhelm, C. Fazakas, A. Tamás, G. Tóth, D. Regl, I.A. Krizbai
J. Mol. Neurosci. 54, 469 (2014).

Dynamic Monitoring of Salmonella typhimurium Infection of Polarized Epithelia Using Organic Transistors
S.A. Tria, M. Ramuz, M. Huerta, P. Leleux, J. Rivnay, L.H. Jimison, A. Hama, G.G. Mall
Adv. Healthcare Mater. 3, 1053 (2014).

Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes
C. Kiatsurayanon, F. Niyonsaba, R. Smithrithee, T. Akiyama, H. Ushio, M. Hara, K. Okumura, S. Ikeda, H. Ogawa
Invest. Dermatol. 134, 2163 (2014).

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice
S.W. Park, J.H. Kim, I Mook-Jung, K.-W. Kim, W.J. Park, K.H. Park, J.H. Kim
Neurobiol Aging. 35, 2013 (2014).

Comprehensive Cysteine-Scanning Mutagenesis Reveals Claudin-2 Pore-Lining Residues with Different Intrapore Locations
J. Li, M. Zhuo, L. Pei, M. Rajagopa, A.S.L. Yu
J. Biol. Chem. 289, 6475 (2014).

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers
M.K. Nøhra, S.H. Hansena, B. Brodin, R. Holm, C.U. Nielsen
Euro. J. Pharm. Sci. 51, 1 (2014).

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
K. Nomura, K. Obata, T. Keira, R. Miyata, S. Hirakawa, K. Takano, T. Kohno, N. Sawada, T. Himi, T. Kojima
Respir. Res. 15, 21 (2014).

In Vitro Models of the Blood–Brain Barrier
C.J. Czupalla, S. Liebner, K. Devraj
Cerebral Angiogenesis Method Molec. Biol. 1135, 415 (2014).

Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis
P. Paganetti, K. Antoniello, K. Devraj, N. Toni, D. Kieran, R. Madani, M. Pihlgren, O. Adolfsson, W. Froestl, A. Schrattenholz, S. Liebner, D. Havas, M. Windisch, J.R. Cirrito, A. Pfeifer, A. Muhs
J. Alzheimer's Disease 38, 767 (2014).

What Is the Mechanism Behind Increased Permeation Rate of a Poorly Soluble Drug from Aqueous Dispersions of an Amorphous Solid Dispersion?
K.J. Frank, U. Westedt, K.M. Rosenblatt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
J. Pharm. Sci. 103, 1779 (2014).

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2013

Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1
O. Rossi , J. Karczewski, E.H. Stolte, R.J.M. Brummer, M.A. van Nieuwenhoven, M. Meijerink, J.R.J. van Neerven, S.C.D. van Ijzendoorn, P. van Baarlen, J.M. Wells
BMC Res. Notes 6, 431 (2013).

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
R. Paolinelli, M. Corada, L. Ferrarini, K. Devraj, C. Artus, C.J. Czupalla, N. Rudini, L. Maddaluno, E. Papa, B. Engelhardt, P.O. Couraud, S. Liebner, E. Dejana
PLoS One 8, e70233 (2013).

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS
S. Bittner, T. Ruck, M.K. Schuhmann, A.M. Herrmann, H. Moha ou Maati, N. Bobak, K. Göbel, F. Langhauser, D. Stegner, P. Ehling, M. Borsotto, H.-C. Pape, B. Nieswandt, C. Kleinschnitz, C. Heurteaux, H.-J. Galla, T. Budde, H. Wiendl, S.G. Meuth
Nat. Med. 19, 1161 (2013).

In vitro intestinal bioavailability of arsenosugar metabolites and presystemic metabolism of thio-dimethylarsinic acid in Caco-2 cells
L. Leffers, C.A. Wehe, S. Hüwel, M. Bartel, F. Ebert, M.S. Taleshi, H.-J. Galla, U. Karst, K.A. Francesconie, T. Schwerdtle
Metallomics 5, 1031 (2013).

Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
D.E. Eigenmann, G. Xue, K.S. Kim KS, A.V. Moses, M. Hamburger, M. Oufir
Fluids Barriers CNS 10, 33 (2013).

Transepithelial permeability studies of flavan-3-ol-C-glucosides and procyanidin dimers and trimers across the Caco-2 cell monolayer
S. Hemmersbach, S.S. Brauer, S. Hüwel, H.J. Galla, H.U. Humpf
J. Agric. Food Chem. 61, 7932 (2013).

The cytokine response of U937-derived macrophages infected through antibody dependent enhancent of dengue virus disrupts cell apical junctional complexes and increase vascular permeability
H. Puerta-Guardo, A. Raya Sandino, L. González-Mariscal, V.H. Rosales, J. Ayala-Dávila, B. Chávez-Mungía, D. Martínez-Fong, F. Medina, J.E. Ludert, R. María del Angel
J. Virol. 87, 7486 (2013).

Acetaminophen Changes Intestinal Epithelial Cell Membrane Properties, Subsequently Affecting Absorption Processes
C. Schäfer, K.R. Schröder, O. Höglinger, S. Tollabimazraehno, M.R. Lornejad-Schäfer
Cell Physiol. Biochem. 32, 431 (2013).

Validation of the organic electrochemical transistor for in vitro toxicology
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biochim. Biophys. Acta 1830, 4381 (2013).

In vitro toxicological characterization of two arsenosugars and their metabolites
L. Leffers, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 57, 1270 (2013).

Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier
I. Meisen, R. Rosenbrück, H.J. Galla, S. Hüwel, I.U. Kouzel, M. Mormann, H. Karch, J. Müthing
Glycobiol. 23, 745 (2013).

Impedance-based cell monitoring: barrier properties and beyond
K. Benson, S. Cramer, H.J. Galla
Fluids Barriers CNS 10, 5 (2013).

Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects.
M. Weidner, S. Hüwel, F. Ebert, T. Schwerdtle, H.J. Galla, H.U. Humpf
PLoS ONE 8, e60484 (2013).

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation
J. Lemmen, I.E.P. Tozakidis, P. Bele, H.J. Galla
Brain Res. 1501, 68 (2013).

Sensing of EGTA Mediated Barrier Tissue Disruption with an Organic Transistor
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biosen. 3, 44 (2013).

Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier
J. Lemmen, I.E.P. Tozakidis, H.J. Galla
Brain Res. 1491, 1 (2013).